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Joshua Mulele Machayo

Joshua Mulele Machayo

Graduate/Research Assistant

Faculty of Science, Engineering and Technology (FSET).

Department of Physical Sciences :Biochemistry Section, 





From 2020-: Master of Science (Life Sciences), Graduate School of Life Sciences, Kyoto University.
Kyoto, Japan.
Undergraduate Studies: Bachelor of Science in Biochemistry, Chuka University, Chuka, Kenya.
2017 and 2018: Research Assistant Trainee, Center for Traditional Medicine and Drug Research
(CTMDR), Kenya Medical Research Institute (KEMRI), Nairobi, Kenya.

Current Research
Cancer cells are characterized by an aberrant increase in proliferation and cellular metabolism,
leading to an imbalance between oxygen supply and oxygen consumption (due to inadequate blood
vessels). Ultimately, these events create a tumor-specific microenvironment, hypoxia, or hypoxic
regions. To survive, cancer cells in a hypoxic environment activate a transcription factor, hypoxiainducible factor 1 (HIF-1), hence acquiring malignant traits and become resistant to radiotherapy
and other anti-cancer agents.
Our research group aims at studying and elucidating molecular mechanisms behind initiation,
progression, and invasion (metastasis), and chemo-/radio-resistance of cancer cells, in hypoxic
regions, for the development of innovative strategies for cancer diagnosis and therapy.
For more information and publications, please visit:
Quote: If it is to be, it is up to you.

Research Interest
I have a strong interest in functional genomics, immunology and the study of cancer (the
biochemistry of cancer).

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